Priligy (dapoxetine) is a potent, selective and fast-acting serotonin reuptake inhibitor. It also plays a role in preventing the reuptake of norepinephrine and dopamine. Researchers believe that the mechanism of dapoxetine is rooted in the inhibition of serotonin’s neuronal reuptake, with subsequent enhancement of its action on the receptors of the sympathetic nervous system. It is the sympathetic nervous system that is responsible for male ejaculation. The peak plasma level of Priligy is reached two hours after administration.
Packs
Pharmacological modulation of ejaculation is a novel concept, radically going beyond the psychosexual model of PE etiopathogenesis. The introduction of serotonin reuptake inhibitors (SSRIs) has revolutionized the approach to the treatment of this disorder. Lots of research concerning the EP were designed incorrectly or errors were made methodological, which makes them not reliable enough.
When conducting studies of all known drugs that are used for PE, the meta-analysis showed only 14.4% effectiveness — dapoxetine ranked first in the list of reliable and effective drugs. Unfortunately, drug treatment also has limited effectiveness: after its termination, the disorder frequently recurs.
Some authors believe that medications should be taken for the whole period of sexual activity. Currently, the best results are achieved when taking medications for a limited period (60 days) in combination with a couple of sexual therapy; the man gains control over his ejaculation and strengthens himself in overcoming PE.
The mechanism of action
Priligy is the only approved medication for treating premature ejaculation (PE) in men aged 18 to 64. It belongs to the class of fast-acting, short-term selective serotonin reuptake inhibitors (SSRIs). Dapoxetine mechanism of action involves the inhibition of serotonin reuptake at neural synapses, which in turn enhances dopaminergic and noradrenergic transmissions. This medication is typically taken “on-demand”, 1-3 hours before sexual activity, once daily. It gets absorbed swiftly in the gastrointestinal tract, achieving its highest plasma level roughly 1 hour after taking it. The drug is rapidly excreted, so it does not accumulate in the body.
The pharmacokinetics of the drug depends on the dose, however, it does not depend on the consumption of food and alcohol. Priligy is metabolized in the liver too, inter alia, desmethyl dapoxetine and dimethyl dapoxetine. The metabolites are eliminated by the kidneys. It is not recommended for use in patients with liver and kidney damage, as well as in patients taking drugs that affect cytochrome P450 (e.g. ketoconazole, ritonavir) and taking other serotonin reuptake inhibitors.
Caution should be exercised in patients with diseases of the cardiovascular system. From the point of view of clinical practice, it is also important that no interactions with phosphodiesterase 5 inhibitors were observed. These pharmacological characteristics set Priligy apart from other selective serotonin reuptake inhibitors.
Indications for use
Priligy is a drug dedicated to men who struggle with premature ejaculation.
The indications for the use of Priligy are:
- premature ejaculation in men aged 18 to 64;
- the intravaginal ejaculation delay time is less than two minutes;
- chronic or recurrent ejaculation with minimal sexual stimulation;
- personal and interpersonal anxiety resulting from premature ejaculation;
- poor control or complete lack of control over ejaculation;
- premature ejaculation in sexual contact within the last six months.
Priligy has proven to be an effective treatment option for premature ejaculation; however, its usage may not be recommended for all men facing this issue.
Contraindications to the use of Priligy are:
- hypersensitivity to any of the ingredients of the preparation;
- moderate or severe liver disorders;
- mania, hypomania, severe depression, or bipolar disorder;
- heart problems, such as heart failure, atrioventricular block, coronary heart disease, valvular disease;
- use of other serotonergic preparations.
Dosages
You can take Priligy with or without food. The initial suggested dose is 30 mg, taken approximately three hours prior to anticipated sexual activity. Depending on its effectiveness, the dose can be adjusted to 60 mg. However, it is important to note that Priligy should not be taken every day on a continuous basis. After taking it for at least six times, you should evaluate the benefits of continued use against the potential risks of frequent dosing.
Side effects
Priligy, like any other drug, may cause various side effects.
They are divided according to the frequency of occurrence:
- dizziness, headaches, and nausea;
- the use of the drug may cause anxiety, agitation, anxiety, insomnia, decreased libido, sleepiness, blurred vision, tinnitus, diarrhea, vomiting, excessive sweating, erectile dysfunction, or irritability;
- depressive mood, euphoria, nightmares, grinding of the teeth, fainting, taste disturbance, increased heart rate, increased blood pressure may uncommonly occur.
Before taking, please review the included leaflet for details on indications, contraindications, potential side effects, and dosage. Additionally, seek advice from your doctor or pharmacist. Misusing any medication can pose serious risks to your health and well-being.
Priligy sum-up
Priligy has been proven effective in treating premature ejaculation, with studies demonstrating its high safety profile and tolerability. On average, the drug increases the duration of intercourse by 3-4 minutes. Notably, dapoxetine can be used as an “on-demand” medication for emergency situations. The drug’s minimal side effects and high effectiveness make it a superior option compared to other PE treatments, which may be less effective or have a higher incidence of adverse effects.
Psychotherapy can be an alternative as well as a method supporting the treatment of PE. The choice of therapy should be discussed with the patient and, if possible, with the partner. The therapy of sexual dysfunctions is currently an increasingly common problem not only in the offices of psychologists, psychiatrists or sexologists, but also a problem faced by internists and cardiologists in their daily medical practice. To sum up, it should be emphasized that the treatment of PE with dapoxetine is possible and should be undertaken by doctors of various specialties, who treat patients with this problem.
Disclaimer:
This patient information is published for educational purposes only. The instructions and product properties quoted on this page follow the guidelines outlines by the drug manufacturer, but do not replicate it in all fullness. We strongly advise against using this information as a call to action of any kind, be it purchasing or using the drug without a proper medical consultation carried out first. Trademarks, names of companies and eventual studies are inserted for informational purposes and as a legal reference and respect for the copyright law and ethics.